A lot of infographics are currently structure from top to down instead of left to right. With that, we scan elements in an infographic like a human body starting from the top to bottom.
Most people are right handed and therefore read from left to right. It also goes by writing that we write from top – down, therefore the quadrant which grabs the most attention is usually the top part (with a differing view on whether the left or right portions are most attention grabbing). Therefore the single “opener” to your problem should be addressed in the top quadrant of the infographic.
Ensure that the body of the story follows through a nice story from the head. Avoid using too many different kinds of visualisations. For example, if your chart is pie chart and bars heavy, stick with it. Avoid using a combo of too many line graphs, bar charts, pie charts and gauges to tell a story. You might also want to give the juiciest bit of your infographic a boost in either size or colour.
When you have led your readers all the way down to the bottom, they need to be able to take away the message with a “What now?” Your conclusion should be structured in big at the end, preferably with some statistics of why the entire infographic even mattered in the first place. Then you leave some references for them to check against the credibility of the data (something like Wikipedia). Also, do not forget to leave a “stamp” or a way for them to get in touch with you.